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AWWA WQTC69458

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AWWA WQTC69458 DNA Damage Assessment in UV-Treated Adenovirus

Conference Proceeding by American Water Works Association, 11/01/2008

Eischeid, Anne C.; Meyer, Joel N.; Linden, Karl G.

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This powerpoint presentation begins by providing a brief overview of Adenoviruses and ultraviolet (UV) disinfection. Previous work showing UV "resistance" was basedon:LP UV-monochromatic at 253.7 nm; and,cell culture infectivity.This work was based on:LP and MP (polychromatic) UV;newer UV technologies, extragenomic damage;QPCR; and,molecular method, direct assessment of damage. Structure of Adenoviruses, infectious cycle of Adenovirus, and QPCR Assay for DNA Damage are presented. Presentation conclusions indicate the following: direct, molecular-based assay does helpclarify effects of UV on adenovirus;DNA damage was the same in both LP and MP;LP UV damage likely gets repaired,allowing successful infection; and,MP UV causes other damage or interfereswith repair. Includes figures.

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Edition: Vol. - No. Published: 11/01/2008 Number of Pages: 8File Size: 1 file , 780 KB